Shocked eye witnesses told The Star the woman was attacked in broad daylight on Blackstock Road, Gleadless, earlier on today.
The incident happened outside the John O Gaunt pub and Gleadless Valley Methodist Church at around 11.55am.
A 44-year-old man has been arrested on suspicion of murder and is in police custody.
Police have cordoned off the area and officers flooded the estate as the investigation got underway.
A South Yorkshire Police spokeswoman said: “At approximately 11.55am, today, Thursday, February 21, police received reports that a woman had been attacked on Blackstock Road in Sheffield.
“The woman, in her 40s, sustained stab wounds and died.
http://www.thestar.co.uk/news/local/video-woman-murdered-in-sheffield-1-5433515
i hate seeing things like this in my own city, im scared to think i might know them, yrs ago i lived up there and have even drank in the pub mentioned